ABSTRACT
Objective To explore the role and mechanisms of 5-HT1Areceptors in the medial septum-diagonal band of Broca complex (MS-DB) in hemiparkinsonian rats. Methods Combined behavioral and electrophysiological studies were performed to assess the role of MS-DB 5-HT1Areceptors in working memory and hippocampal theta rhythm in rats with 6-hydroxydopamine (6-OHDA)lesions in the medial forebrain bundle (MFB).Results ① MFB lesions in the rats decreased choice accuracy in the T-maze rewarded alternation test. Intra-MS-DB injection of 5-HT1Areceptor agonist 8-OH-DPAT further decreased choice accuracy,while intra-MS-DB injection of 5-HT1Areceptor antagonist WAY-100635 increased choice accuracy in the lesioned rats.② MFB lesions in the rats decreased peak theta rhythm frequency. Intra-MS-DB injection of 8-OH-DPAT suppressed hippocampal theta rhythm and decreased normalized theta power,while intra-MS-DB injection of WAY-100635 induced theta rhythm and increased normalized theta power.Conclusion Blockade of MS-DB 5-HT1Areceptors can recover cognitive dysfunction in Parkinson's disease, which may be attributed to the enhancement of hippocampal theta rhythm.
ABSTRACT
Objective To observe the changes in noninvasive hemodynamic parameters in patients with chronic heart failure (CHF) at different stages of development,and to explore the clinical significance of related parameters.Methods A total of 119 patients who had been hospitalized in the Heart Center of our hospital between March 2014 and Orctober 2016 were divided into phases A,B,and C according to the ACC/AHA Progression Criteria for Chronic Heart failure.Phase A was pre heart failure group A,phase B was pre clinical heart failure stage group B,and phase C was the clinical stage of heart failure group C.Meanwhile,39 healthy people in our hospital were chosen as group O.Their clinical data,serum BNP levels and LVEF values were collected,the noninvasive hemodynamic indexes of heart function were recorded by the noninvasive cardiac function detection system,including stroke volume (SV),cardiac output (CO),cardiac index (CI),systolic C wave amplitude,cardiac contractility index (HI),systolic function of heart contractility index (Q-B/B-X),pulmonary artery wedge pressure (PCWP),left ventricular end diastolic pressure (LVEDP),aortic compliance (AC) and total peripheral resistance (TPR).Comparative analysis of noninvasive hemodynamic indexes and changes in BNP and LVEF in different stages of CHF was conducted.Results The levels of C,SV,CO,CI,AC and HI in groups A,B and C were lower than those in control group (P ＜0.05),while Q-B/B-X,PCWP,LVEDP,and TPR were higher than those in the control group (P ＜ 0.05).C,CI,and HI decreased more significantly,but Q-B/B-X,PCWP,and LVEDP increased with the development of heart failure (P ＜ 0.05).BNP was significantly higher in group C than in normal control group (P ＜ 0.05),but there was no significant difference between group A and B.LVEF in group C was significantly lower than that in group O (P ＜ 0.05).There were negative correlations between SV,CO,CI,C,HI,AC and LVEF at different stages of heart failure,but there were positive correlations between Q-B/B-B,PCWP,LVEDP,TPR,and BNP.Receiver operating characteristics curve analysis further indicated the value of the noninvasive hemodynamic parameters C,CI,HI and Q-B/B-X in evaluation of cardiac function in the early stage of heart failure.Conclusion The changes in noninvasive hemodynamic parameters are consistent with the different stages of heart failure,which can provide an objective reference for early evaluation of cardiac function.